細胞衰老是細胞停止分裂的現(xiàn)象。衰老可由內(nèi)部(氧化應(yīng)激近年來、DNA損傷等)和外部(毒素著力增加、紫外線等)因素誘導(dǎo)傳承。衰老是一種生長停滯的狀態(tài)又進了一步,細胞在這種狀態(tài)下保持活力但停止分裂基礎。衰老細胞表現(xiàn)出細胞大小增加同時,β-半乳糖苷酶逐步改善、p53和P16活性的衰老相關(guān)表達,以及基因表達模式的改變集中展示。
SentraGortech的衰老檢測試劑實力增強,檢測衰老,口碑好探索創新,文獻多帶來全新智能。靶點科技作為授權(quán)代理商,常備現(xiàn)貨新產品,歡迎訂購咨詢更優質。
SenTraGor™ (GL13) is an innovative reagent for the detection of senescence. Senescent cells play a potent role in normal development, tissue homeostasis, aging and a wide spectrum of age related disorders. Up to now, a major problem in the field of senescence was the absence of a reliable marker to specifically detect these cells, especially in situ. SenTraGor™ (GL13) is a biotinylated Sudan Black B based chemical reagent that was designed to overcome this constraint.
SenTraGor™ (GL13) staining allows the detection of senescence in any biological material. Direct visualization of senescent cells can be achieved in all archival tissue specimens (formalin-fixed paraffin-embedded) and cells from biopsies or cell cultures.
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