腸道巨噬細(xì)胞代表了多種的常駐組織巨噬細(xì)胞來(lái)源 [1, 2]。腸道常駐巨噬細(xì)胞是一種重要的免疫群體性能，能夠在其環(huán)境中整合和解釋不同的食物來(lái)源多種方式、共生來(lái)源、病原體來(lái)源和宿主來(lái)源的信號(hào)新創新即將到來。此外邁出了重要的一步，在炎癥反應(yīng)下，BM 衍生的腸道巨噬細(xì)胞和常駐巨噬細(xì)胞在控制感染中起關(guān)鍵作用重要工具。因此，腸道巨噬細(xì)胞池的動(dòng)態(tài)調(diào)節(jié)是長(zhǎng)期健康的核心[3]配套設備。補(bǔ)充健康腸道中常駐池的 BM 衍生巨噬細(xì)胞被確定為 CX3CR1hiMHCIIhiLy6Clow [103]更優質，它們?cè)谀c道穩(wěn)態(tài)中具有多種關(guān)鍵功能，包括 Treg 擴(kuò)增推進高水平、上皮維持脫穎而出、管腔取樣和細(xì)菌殺滅 [4, 5]。如表 4 所示生產創效，腸道和真皮被認(rèn)為是開(kāi)放組織結構，具有快速募集和分化骨髓來(lái)源的單核細(xì)胞成巨噬細(xì)胞的動(dòng)力學(xué)。盡管在出生時(shí)優化上下，腸道中存在胚胎衍生的巨噬細(xì)胞能力建設，但這些巨噬細(xì)胞被來(lái)自大量 CCR2 依賴(lài)性 Ly6Chi 單核細(xì)胞的細(xì)胞所取代[6]模樣。巨噬細(xì)胞上的 IL-10 受體信號(hào)傳導(dǎo)是一種對(duì)指導(dǎo)胃腸粘膜中巨噬細(xì)胞功能至關(guān)重要的途徑 [7, 8]。
如何研究腸道巨噬細(xì)胞的功能服務？一個(gè)強(qiáng)有力的工具就是清除腸道巨噬細(xì)胞很重要。靶點(diǎn)科技庫(kù)存大量LIPOSOMA的ClodronateLiposomes氯膦酸二鈉脂質(zhì)體。作為授權(quán)的中國(guó)Exclusive Distributor覆蓋，無(wú)論從產(chǎn)品質(zhì)量還是技術(shù)支持異常狀況，都能給予從理論到實(shí)踐的賦能。
參考文獻(xiàn)
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2. Lee S, Starkey P, Gordon S. Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80. J Exp Med. 1985;161:475-89
3. Grainger J, Konkel J, Zangerle Murray T, Shaw T. Macrophages in gastrointestinal homeostasis and inflammation. Pflugers Arch. 2017;469:527-539
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6. Smythies L, Sellers M, Clements R, Mosteller Barnum M, Meng G, Benjamin W, et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest. 2005;115:66-75
7. Bain C, Bravo Blas A, Scott C, Perdiguero E, Geissmann F, Henri S, et al. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nat Immunol. 2014;15:929-937
8. Shouval D, Biswas A, Goettel J, McCann K, Conaway E, Redhu N, et al. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014;40:706-19
9. Zigmond E, Bernshtein B, Friedlander G, Walker C, Yona S, Kim K, et al. Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis. Immunity. 2014;40:720-33
